Compositions and methods for treatment of pain

ABSTRACT

The present invention relates to a homeopathic formulation comprising dilutions of  Arnica, Calendula, Echinacea, Hypericum , Silver, Sulfur,  Thiosinaminum ,  Urtica , and methods for treating pain, inflammation, scar tissue, itching/pruritus and infection using same.

CROSS-REFERENCE TO RELATED APPLICATIONS

The present application is a continuation of U.S. 14/384,823, filed Sep.12, 2014, which is a national phase entry under 35 U.S.C. §371 ofInternational Application No. PCT/US2013/030448 filed Mar. 12, 2013,which claims priority to U.S. patent application No. 61/685,352 filedMar. 15, 2012, all of which are hereby incorporated herein by reference.

BACKGROUND OF THE INVENTION

Historically aches, pains and bodily discomfort have engaged people, aswell as their animals and pets, for thousands of years. Yet, when onelooks at the pain remediation marketplace of today, it becomes apparentthat no one product has as yet been developed that has the ability tooffer one hundred percent relief, particularly pain relief to any oneindividual. As such, people today desiring to reduce or stop theirsuffering from pain/aches and/or pruritus will often attempt to seekrelief from the use of one or more drugs from the category ofnon-prescription and/or prescription drugs that are in fairly largeabundance worldwide, with hundreds from which to choose.

Unfortunately many of these drugs have unwanted side effects that canoften compromise health and well-being; they include overdosing, severeallergic and/or hypersensitivity reactions, unsightly rashes, moderateto severe breathing difficulties, suicidal thoughts, blurry vision,gastric upset, and liver dysfunction. These drugs can also cause death,even when drug instructions are followed assiduously. Clearly there is aneed for a safer if not a better alternative.

BRIEF SUMMARY OF THE INVENTION

A homeopathic formulation of the present invention comprises at leastone dilution of Arnica, at least one dilution of Calendula, at least onedilution of Echinacea, at least one dilution of Hypericum, at least onedilution of Silver, at least one dilution of Sulfur, at least onedilution of Thiosinaminum, and at least one dilution of Urtica. In oneembodiment, the dilutions of Arnica, Calendula, Echinacea, Hypericum,Silver, Sulfur, Thiosinaminum, and Urtica include dilutions of C and Mpotencies. In some embodiments, the C potency of the dilutions ofArnica, Calendula, Echinacea, Hypericum, Silver, Sulfur, Thiosinaminum,and Urtica ranges from about 5 C to about 50 C. In other embodiments,the M potency of the dilutions of Arnica, Calendula, Echinacea,Hypericum, Silver, Sulfur, Thiosinaminum, and Urtica ranges from about 5M to about 100 M. In various embodiments, the formulation of the presentinvention further comprises at least one dilutions of Nosode. In someembodiments, the Nosode comprises an infection agent such as one or moreselected from the group consisting of Methicillin-resistantStaphylococcus aureus (MRSA), microplasms, Aspergillus niger, Candida,Mucor racemosus, Gram-negative bacteria, and Gram-positive bacteria. Inone embodiment, the formulation further comprises an inactiveingredient.

In some embodiments, the formulation of the present invention can beused to treat pain, inflammation and/or infection. In variousembodiments, the formulation of present invention can be sued byapplying the topical spray of the formulation of directly onto an areaof concern on the outside or inside a patient's body.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a photograph of the burn wounds on hand.

FIG. 2 is a photograph showing the results after the composition inaccordance with the present invention was applied to the burn wounds onhand as shown in FIG. 1.

FIG. 3 is a photograph of Cellulitis on a leg of a male patient.

FIG. 4 is a photograph of the results of the composition in accordancewith the present invention was applied to the Cellulitis on the leg asshown in FIG. 3.

DETAILED DESCRIPTION

The present invention will be described in more detail below.

All percentages and ratios used herein are by weight of the totalcomposition and all measurements made are at about room temperature andnormal pressure unless otherwise designated. “Room temperature” asdefined herein means a temperature ranging between about 22° C. andabout 26° C. All temperatures are in degrees Celsius unless specifiedotherwise.

The present invention can “comprise” (open ended) or “consistessentially of” the components of the present invention as well as otheringredients or elements described herein. As used herein, “comprising”means the elements recited, or their equivalent in structure orfunction, plus any other element or elements which are not recited. Theterms “having” and “including” are also to be construed as open endedunless the context suggests otherwise.

As used herein, “consisting essentially of” means that the invention mayinclude ingredients in addition to those recited in the claim, but onlyif the additional ingredients do not materially alter the basic andnovel characteristics of the claimed invention. Preferably, suchadditional ingredients will not be present at all or only in traceamounts. However, it may be possible to include up to about 10% byweight of materials that could materially alter the basic and novelcharacteristics of the invention as long as the utility of the compounds(as opposed to the degree of utility) is maintained.

All ranges recited herein include the endpoints, including those thatrecite a range “between” two values. Terms such as “about,” “generally,”“substantially,” and the like are to be construed as modifying a term orvalue such that it is not an absolute, but does not read on the priorart. Such terms will be defined by the circumstances and the terms thatthey modify as those terms are understood by those of skill in the art.This includes, at very least, the degree of expected experimental error,technique error and instrument error for a given technique used tomeasure a value.

Note that while the specification and claims may refer to a finalproduct containing a certain reactant or a certain amount, it may bedifficult to tell from the product that any particular recitation issatisfied. Such a recitation may be satisfied, however, if the materialsused prior to final production, for example, meet that recitation.Indeed, as to any property or characteristic of a final product whichcannot be ascertained from the final product directly, it is sufficientif that property resides in the components recited just prior toproduction steps used to make the composition.

As used herein, a “homeopathic formulation” is defined as a formulationincluding at least one tincture of a drug labeled as being homeopathic,which is listed in the Homeopathic Pharmacopeia of the United States(HPUS).

Dilution

A homeopathic formulation begins with a mother tincture, which means aremedy (e.g., a medicinal substance or Nosode) to be used dissolved inwater or alcohol. The mother tincture can be diluted. For example, ifthe mother tincture is diluted by 1 part in 100 of water (1:100), it isknown as a “C” potency. If another dilution is then done to the 1Cdilution, a 2C dilution (1 part mother tincture in 10,000 of water) canbe produced. A further 1C dilution of the 2C dilution can produce a 3Cdilution (1 part mother tincture in 1,000,000 of water). The iterationcan be repeated to produce formulation of differing potency.

If the mother tincture is diluted by 1 part in 10 (1:10), it is known as“X” potency. If the mother tincture is diluted by 1 part in 1000(1:1000), then it is known as “M” potency. The iteration of 1X and 1Mcan be repeated, respectively, to produce formulation of differingpotency.

Various dilutions can be made from a mother tincture as discussed above.In some embodiments, these dilutions can be blended together to producea final formulation. For example, a mother tincture of an ingredient 1,I₁, can be used to form dilutions of 10C, 30C, and 50M, symbolized by:I₁10C and I₁30C and I₁50M, respectively. Then, certain amounts of thesedifferent dilutions having different potency can be blended together toproduce a final formulation.

Blending

There are numerous strategies/techniques that could be used to blenddilutions together. For example, equal or differing volumes of dilutionscould be blended together. In one embodiment, equal volumes of thedilutions of the same ingredient, I₁, could be blended together asillustrated in Table 1 below to produce a formulation:

TABLE 1 Ingredient Potency Amount I₁ 10C 1 liter 30C 1 liter 50M 1 literFINAL FORMULATION 3 liter of I₁10C/30C/50M

In other embodiments, a formulation can include blended dilutions ofvarious ingredients by equal or differing volumes of dilutions. Belowdescribes various blending strategies which can be used to produce afinal homeopathic formulation in accordance with the present invention.

Some blending strategies can include forming blends, C_(k), of variousingredients, I_(i), at specific dilutions, D_(k), and then furtherblending the blends, C_(k), together. For example, a blend of variousC_(k) may described by the Formula I below:Σ C _(k) =ΣD _(k)(Σ I _(i))  Formula I

For example,C ₁ =I ₁10C+I ₂10C+ . . . +I _(i)10C, wherein D ₁=10C;C ₂ =I ₁30C+I ₂30C+ . . . +I _(i)30C, wherein D ₂=30C; andC ₃ =I ₁50M+I ₂50M+ . . . +I _(i)50M, wherein D ₃=50M.

Yet other blending strategies can be employed, such as producing ablended volume equal to the volume of each starting dilution. Forexample, in such a strategy, fractional volumes of each dilution can beused to form a blend. Below Table 2 illustrates a non-limitingillustration of such blending strategy:

TABLE 2 Fractional Volume Dilution 5/26 3 liters of I₁10C 8/26 3 litersof I₁30C 13/26 3 liters of I₁50C FINAL FORMULATION 3 liter ofI₁10C/30C/50C

Similar blends can be made for additional ingredients. The blends ofvarious ingredients can be further mixed together. Thus, many blendingstrategies can be utilized to produce the product herein taught.

Other blending strategies are possible, such as any of those thatutilize aspects of mathematics, harmonic ordering, quantum resonance,probabilities, weighted averages, or other various mathematical and/orscientific theories and/or formalisms.

Succussion

In some embodiments, a diluted formulation of a mother tincture, forexample, as discussed above, can be agitated by a process known as“succussion”. Succussion may include shaking a formulation vigorously,staccato stirring, or otherwise agitating the formulation or blend in asuitable container/vessel, such as one made from PET, glass, orstainless steel. Succussion techniques can employ either or both ofthose of Hahnemann and Korsakov, and can be performed by hand and/orwith suitable equipment, such as those from LABOTICS, such as a Dynamat,Impregmat or K-Tronic. Succussion can improve retention of theproperties of the mother tincture in the dilution. One or moresuccussion techniques can be performed at any stage or iteration of themanufacturing process, for example, on one or more dilutions prior toblending those dilutions, or on the blended product of those dilutions,or on some dilutions but not other dilutions, or the like. The same ordifferent succussion techniques can be applied to each dilution or blendat any stage of the manufacturing process.

One or more succussions can be performed during one or more iterations,each iteration occurring for a time interval. The number of successionsthat can be performed during each iteration can range from about 10 toabout 1000, preferably about 15 to about 150. The time interval of eachiteration may be constant or variable. In some embodiments, the timeinterval of each iteration may range from about 6 seconds to about 150seconds, preferably about 20 seconds to about 40 seconds.

In some embodiments, a number of succussions per iteration can bepatterned to a mathematical series, S, such as a Fibonacci series or anysuitable series, with a harmonic multiplier, H, as described by theFormula II below:

$\begin{matrix}{{{\sum\limits_{i = a}^{k}{\left( S_{i} \right)H}}}_{V}^{T_{function}} = U} & {{Formula}\mspace{14mu}{II}}\end{matrix}$

The harmonic multiplier can be constant or variable, such as dependenton a mathematical function. For example, “k” iterative succussions canbe performed to a volume, V, within a constant time interval using aFibonacci Series, S=1, 1, 2, 3, 5, 8, 13, 21, 34, 55 . . . n, modifiedby a harmonic multiplier, H, which is a constant and equal to 10 in thisexample. Using the exemplary succussion pattern described above ofFormula II, this Volume, V, would experience the sum total ofsuccussions, U, where U=1430 succussions as shown by Table 3 below.

TABLE 3 Iteration Number of Succussions Time Interval (min) 1 10 1 2 101 3 20 1 4 30 1 5 50 1 6 80 1 7 130 1 8 210 1 9 340 1 10 550 1 TOTAL1430 SUCCUSSIONS

Other succussion strategies are possible, such as any of those thatutilize aspects of mathematics, harmonic ordering, quantum resonance,probabilities, weighted averages, or other various mathematical and/orscientific theories and/or formalisms.

Arnica

Arnica has been used for medicinal purposes since the 1500s. In generalthe constituent base is complex, consisting of a wide variety ofchemicals of variable effect and potency; for example, one such complexcan contain derivatives of thymol also known as2-isopropyl-5-methylphenol, a naturally occurring biocide with strongantimicrobial/anti-fungal attributes that can reduce bacterialresistance to common drugs such as penicillin. Numerous studies havedemonstrated its antimicrobial (including Aeromoans hydrophila andStaphylococcus aureus) effects, ranging from inducing antibioticsusceptibility in drug-resistant pathogens to powerful antioxidantproperties, and to reduce bacterial resistance to antibiotics through asynergistic effect; it has also been shown to be effective particularlyagainst Fluconazole-resistant strains, and there is evidence ofanti-tumor properties. Arnica can be used to reduce inflammation, toheal wounds, and/or for injuries such as sprains and bruises. Arnica canbe used to speed recovery from soreness and bruising associated withsurgery. Homeopathic formulations in accordance of the present inventioncan include tinctures and/or dilutions of Arnica. In some embodiments, amother tincture of Arnica can include about 1 to about 30 grams ofArnica dissolved in about 30 to about 60 ml of water and/or alcohol.Various dilutions can be made from the mother tincture. Dilutions ofArnica may include X, C and M dilutions. X dilutions may range inpotency from about mother tincture to about 500 X; about 2 X to about300 X; about 5 X to about 100 X; about 5 X to about 50 X. C dilutionsmay range in potency from mother tincture to about 500 C; about 2 C toabout 300 C; about 5 C to about 100 C; about 5 C to about 50C. Mdilutions may range in potency from about mother tincture to about 1000M; about 2 M to about 300 M; about 5 M to about 200 M; about 5M to about100 M. Succussion can be performed on any Arnica dilution, prior to, orafter blending to form a homeopathic formulation. In some embodiments,homeopathic formulations can be made from Arnica dilutions of 10C. Inother embodiments, homeopathic formulations can be made from Arnicadilutions of 30C. In yet other embodiments, homeopathic formulations canbe made from Arnica dilutions of 50M. In another embodiment, homeopathicformulations is a blended formulation including various Arnicadilutions. Examples of such blended formulation, without limitation,includes blended formulation of 10C/30C/50M, 10C/100C/100M, 5C/30C/50M,30C/100C/200M and 100C/200C/1000M, Homeopathic formulations may includeArnica dilutions in an amount ranging from about 5% to about 40%, about10% to about 20% relative to the total volume of the final formulation.

Calendula

Calendula plant pharmacological studies have suggested that Calendulaextracts may have antiviral, antigenotoxic, cytotoxic anti-tumor,anti-inflammatory and lymphocyte activation properties. Users in trialsalso experienced less radiation induced pain and fewer breaks intreatment. Homeopathic formulations in accordance of the presentinvention can include tinctures and/or dilutions of Calendula. In someembodiments, a mother tincture of Calendula can include about 1 to about30 grams of Arnica dissolved in about 30 to about 60 ml of water and/oralcohol. Various dilutions can be made from the mother tincture.Dilutions of Calendula may include X, C and M dilutions. X dilutions mayrange in potency from about mother tincture to about 500 X; about 2 X toabout 300 X; about 5 X to about 100 X; about 5 X to about 50X. Cdilutions may range in potency from mother tincture to about 500 C;about 2 C to about 300 C; about 5 C to about 100 C; about 5 C to about50C. M dilutions may range in potency from about mother tincture toabout 1000 M; about 2 M to about 300 M; about 5 M to about 200 M; about5 M to about 100 M. Succussion can be performed on any Calenduladilution, prior to, or after blending to form a homeopathic formulation.In some embodiments, homeopathic formations can be made from includeCalendula dilutions of 10C. In other embodiments, homeopathicformulations can be made from Calendula dilutions of 30C. In yet otherembodiments, homeopathic formulations can be made from Calenduladilutions of 50M, In another embodiment, homeopathic formulations is ablended formulation including various Calendula dilutions. Examples ofsuch blended formulation, without limitation, includes blendedformulation of 10C/30C/50M, 10C/100C/100M, 5C/30C/50M, 30C/100C/200M and100C/200C/1000M. Homeopathic formulations may include Calenduladilutions in an amount ranging from about 5% to about 40%, about 10% toabout 20% relative to the total volume of the final formulation

Echinacea

Archaeologists have found evidence that Native Americans may have usedEchinacea for more than 400 years to treat infection and wounds. Today'suses include a method to shorten the duration of the common cold and fluand reduce symptoms, such as sore throat/pharyngitis, cough, and fever.Several laboratory and animal studies suggest that it contains activesubstances that enhance the activity of the immune system, relieve pain,reduce inflammation, and have hormonal, antiviral, and antioxidanteffects. Often recommended to treat urinary tract infections, vaginalyeast (Candida) infections, ear infections, athlete's foot, sinusitis,hay fever/allergic rhinitis, as well as slow-healing wounds. Theconstituent base for echinacea is complex, consisting of a wide varietyof chemicals of variable effect and potency. Some chemicals may bedirectly antimicrobial, while others may work at stimulating ormodulating different parts of the immune system. Chemical constituentsinclude phenols (cichoric acid and caftaric acid); others that may haveimportant health effects include alkylamides and polysaccharides. Theimmunomodulatory effects of echinacea preparations are likely caused byfat-soluble alkylamides (alkamides). Alkylamides bind particularly tohuman CB2 and to a much lesser degree to CB1 receptors; as a result theyare implicated in a variety of modulatory functions, including immunesuppression, induction of apoptosis, cell migration and inhibition oftumor necrosis factor α TNF-alpha. Although the triggering factors formany autoimmune diseases are not known, one of the key inflammatorymediators in the attending chronic inflammatory process is the cytokine,tumor necrosis factor-alpha (TNF-α). TNF-α overexpression acts as adriver for inflammation that damages cartilage, bone and bowel mucosa,and TNF-α inhibition leads to significant clinical improvements andreduction of this damage.

Homeopathic formulations in accordance of the present invention caninclude tinctures and/or dilutions of Echinacea. In some embodiments, amother tincture of Echinacea can include about 1 to about 30 grams ofEchinacea dissolved in about 30 to about 60 ml of water and/or alcohol.Various dilutions can be made from the mother tincture. Dilutions ofEchinacea may include X, C and M dilutions. X dilutions may range inpotency from about mother tincture to about 500 X; about 2 X to about300 X; about 5 X to about 100 X; about 5 X to about 50X. C dilutions mayrange in potency from mother tincture to about 500 C; about 2 C to about300 C; about 5 C to about 100 C; about 5 C to about 50 C. M dilutionsmay range in potency from about mother tincture to about 1000 M; about 2M to about 300 M; about 5 M to about 200 M; about 5 M to about 100 M.Succussion can be performed on any Echinacea dilution, prior to, orafter blending to form a homeopathic formulation. In some embodiments,homeopathic formations can be made from include. Echinacea dilutions of10C. In other embodiments, homeopathic formulations can be made fromEchinacea dilutions of 30C. In yet other embodiments, homeopathicformulations can be made from Echinacea dilutions of 50M. In anotherembodiment, homeopathic formulations is a blended formulation includingvarious Echinacea dilutions. Examples of such blended formulation,without limitation, includes blended formulation of 10C/30C/50M,10C/100C/100M, 5C/30C/50M, 30C/100C/200M and 100C/200C/1000M.Homeopathic formulations may include Echinacea dilutions in an amountranging from about 5% to about 40%, about 10% to about 20% relative tothe total volume of the final formulation

Hypericum

Hypericum has a history of being used as a medicine dating back toancient Greece with antibacterial and antiviral properties. Itsanti-inflammatory properties are useful when applied to the skin to helpheal not only wounds and burns, but also eczema and hemorrhoids. Inrecent years it has been studied extensively as a treatment fordepression. A number of studies show that it may help treatmild-to-moderate depression. An early study suggests that it may alsohelp relieve physical and emotional symptoms of Premenstrualsyndrome/PMS in some women, including cramps, irritability, foodcravings, and breast tenderness. It may also help to improve mood andanxiety during menopause.

Homeopathic formulations in accordance of the present invention caninclude tinctures and/or dilutions of Hypericum. In some embodiments, amother tincture of Hypericum can include about 1 to about 30 grams ofHypericum dissolved in about 30 to about 60 ml of water and/or alcohol.Various dilutions can be made from the mother tincture. Dilutions ofHypericum may include X, C and M dilutions. X dilutions may range inpotency from about mother tincture to about 500 X; about 2 X to about300 X; about 5 X to about 100 X; about 5 X to about 50X. C dilutions mayrange in potency from mother tincture to about 500 C; about 2 C to about300 C; about 5 C to about 100 C; about 5 C to about 50C. M dilutions mayrange in potency from about mother tincture to about 1000 M; about 2 Mto about 300 M; about 5 M to about 200 M; about 5 M to about 100 M.Succussion can be performed on any Hypericum dilution, prior to, orafter blending to form a homeopathic formulation. In some embodiments,homeopathic formations can be made from include Hypericum dilutions of10C. In other embodiments, homeopathic formulations can be made fromHypericum dilutions of 30C. In yet other embodiments, homeopathicformulations can be made from Hypericum dilutions of 50M. In anotherembodiment, homeopathic formulations is a blended formulation includingvarious Hypericum dilutions. Examples of such blended formulation,without limitation, includes blended formulation of 10C/30C/50M,10C/100C/100M, 5C/30C/50M, 30C/100C/200M and 100C/200C/1000M.Homeopathic formulations may include Hypericum dilutions in an amountranging from about 5% to about 40%, about 10% to about 20% relative tothe total volume of the final formulation

Thiosinaminum

Thiosinaminum is a trituration of the crystals of allyl sulphocarbamide.Uses include resorbing/dissolving/reduction of scar tissue/fibrosis,tumors, strictures, plantar fasciitis, immune system diseases, enlargedglands, eye concerns, scleroderma, tinnitus aurium, amenorrhea, cysticfibrosis, polycystic ovaries, fibroids and pelvic adhesions. Homeopathicformulations in accordance of the present invention can includetinctures and/or dilutions of Thiosinaminum. In some embodiments, amother tincture of Thiosinaminum can include about 1 to about 30 gramsof Thiosinaminum dissolved in about 30 to about 60 ml of water and/oralcohol. Various dilutions can be made from the mother tincture.Dilutions of Thiosinaminum may include X, C and M dilutions. X dilutionsmay range in potency from about mother tincture to about 500 X; about 2X to about 300 X; about 5 X to about 100 X; about 5 X to about 50X. Cdilutions may range in potency from mother tincture to about 500 C;about 2 C to about 300 C; about 5 C to about 100 C; about 5 C to about50C. M dilutions may range in potency from about mother tincture toabout 1000 M; about 2 M to about 300 M; about 5 M to about 200 M; about5 M to about 100 M. Succussion can be performed on any Thiosinaminumdilution, prior to, or after blending to form a homeopathic formulation.In some embodiments, homeopathic formations can be made from includeThiosinaminum dilutions of 10C. In other embodiments, homeopathicformulations can be made from Thiosinaminumdilutions of 30C. In yetother embodiments, homeopathic formulations can be made fromThiosinaminum dilutions of 50M. In another embodiment, homeopathicformulations is a blended formulation including various Thiosinaminumdilutions. Examples of such blended formulation, without limitation,includes blended formulation of 10C/30C/50M, 10C/100C/100M, 5C/30C/50M,30C/100C/200M and 100C/200C/1000M. Homeopathic formulations may includeThiosinaminum dilutions in an amount ranging from about 5% to about 40%,about 10% to about 20% relative to the total volume of the finalformulation.

Silver

Silver has a proven record of broad-spectrum antimicrobial activity thatincludes antibiotic-resistant bacteria, with minimal toxicity towardmammalian cells at low concentrations, and has a less likely tendencythan antibiotics to induce resistance due to its activity at multiplebacterial target sites. Silver combined with sulfur is used to topicallytreat infections of second- and third-degree burns. Wound dressings thatcontain silver are increasing in importance due to the recent increaseof antibiotic-resistant bacteria, such as MRSA. Homeopathic formulationsin accordance of the present invention can include tinctures and/ordilutions of Silver. In some embodiments, a mother tincture of Silvercan include about 0.1 to about 3 grams of Silver dissolved in about 30to about 60 ml of water and/or alcohol. Various dilutions can be madefrom the mother tincture. Dilutions of Silver may include X, C and Mdilutions. X dilutions may range in potency from about mother tinctureto about 500 X; about 2 X to about 300 X; about 5 X to about 100 X;about 5 X to about 50X. C dilutions may range in potency from mothertincture to about 500 C; about 2 C to about 300 C; about 5 C to about100 C; about 5 C to about 50C. M dilutions may range in potency fromabout mother tincture to about 1000 M; about 2 M to about 300 M; about 5M to about 200 M; about 5 M to about 100 M. Succussion can be performedon any Silver dilution, prior to, or after blending to form ahomeopathic formulation. In some embodiments, homeopathic formations canbe made from include Silver dilutions of 10C. In other embodiments,homeopathic formulations can be made from Silver dilutions of 30C. Inyet other embodiments, homeopathic formulations can be made from Silverdilutions of 50M. In another embodiment, homeopathic formulations is ablended formulation including various Silver dilutions. Examples of suchblended formulation, without limitation, includes blended formulation of10C/30C/50M, 10C/100C/100M, 5C/30C/50M, 30C/100C/200M and100C/200C/1000M. Homeopathic formulations may include Silver dilutionsin an amount ranging from about 5% to about 40%, about 10% to about 20%relative to the total volume of the final formulation.

In addition to including Silver dilutions in the homeopathicformulation, Silver can be further added to the homeopathic formulationas an inactive ingredient, for example, as a preservative.

Sulfur

Sulfur has been in therapeutic use for over 2,000 years, especially forits antiseptic attributes. Sulfur also helps to controlitching/irritation. Sulfur combined with silver is used to topicallytreat infections of second- and third-degree burns; it also kills a widevariety of bacteria. Also used in the treatment of skin disorders andirritations, such as eczema, dandruff, folliculitis, warts, pityriasisversicolor, psoriasis and acne. It has natural antiseptic properties andplays an essential role in the synthesis of collagen. Well-designedstudies, most conducted in Israel, suggest that balneotherapy/sulfur canhelp treat several different kinds of arthritis. People who took sulfurbaths and other spa therapies improved strength, had less morningstiffness, had better walking ability, and less inflammation, swelling,and pain in joints, particularly in the neck and back.

Homeopathic formulations in accordance of the present invention caninclude tinctures and/or dilutions of Sulfur. In some embodiments, amother tincture of Sulfur can include about 1 to about 30 grams ofSulfur dissolved in about 30 to about 60 ml of water and/or alcohol.Various dilutions can be made from the mother tincture. Dilutions ofSulfur may include X, C and M dilutions. X dilutions may range inpotency from about mother tincture to about 500 X; about 2 X to about300 X; about 5 X to about 100 X; about 5 X to about 50X. C dilutions mayrange in potency from mother tincture to about 500 C; about 2 C to about300 C; about 5 C to about 100 C; about 5 C to about 50C. M dilutions mayrange in potency from about mother tincture to about 1000 M; about 2 Mto about 300 M; about 5 M to about 200 M; about 5 M to about 100 M.Succussion can be performed on any Sulfur dilution, prior to, or afterblending to form a homeopathic formulation. In some embodiments,homeopathic formations can be made from include Sulfur dilutions of 10C.In other embodiments, homeopathic formulations can be made from Sulfurdilutions of 30C. In yet other embodiments, homeopathic formulations canbe made from Sulfur dilutions of 50M. In another embodiment, homeopathicformulations is a blended formulation including various Sulfurdilutions. Examples of such blended formulation, without limitation,includes blended formulation of 10C/30C/50M, 10C/100C/100M, 5C/30C/50M,30C/100C/200M and 100C/200C/1000M. Homeopathic formulations may includeSulfur dilutions in an amount ranging from about 5% to about 40%, about10% to about 20% relative to the total volume of the final formulation.

Urtica

Urtica has been used for hundreds of years to treat painful muscles andjoints, eczema, arthritis and gout. Today it is also used to treaturinary problems during the early stages of benign prostatichyperplasia, for urinary tract infections, for hay fever/allergicrhinitis (reduced sneezing and itching), or for treating joint pain,sprains and strains, tendonitis, and insect bites. Homeopathicformulations in accordance of the present invention can includetinctures and/or dilutions of Urtica. In some embodiments, a mothertincture of Urtica can include about 1 to about 30 grams of Urticadissolved in about 30 to about 60 ml of water and/or alcohol. Variousdilutions can be made from the mother tincture. Dilutions of Urtica mayinclude X, C and M dilutions. X dilutions may range in potency fromabout mother tincture to about 500 X; about 2 X to about 300 X; about 5X to about 100 X; about 5 X to about 50X. C dilutions may range inpotency from mother tincture to about 500 C; about 2 C to about 300 C;about 5 C to about 100 C; about 5 C to about 50C. M dilutions may rangein potency from about mother tincture to about 1000 M; about 2 M toabout 300 M; about 5 M to about 200 M; about 5 M to about 100 M.Succussion can be performed on any Urtica dilution, prior to, or afterblending to form a homeopathic formulation. In some embodiments,homeopathic formations can be made from include Urtica dilutions of 10C.In other embodiments, homeopathic formulations can be made from Urticadilutions of 30C. In yet other embodiments, homeopathic formulations canbe made from Urtica dilutions of 50M. In another embodiment, homeopathicformulations is a blended formulation including various Urticadilutions. Examples of such blended formulation, without limitation,includes blended formulation of 10C/30C/50M, 10C/100C/100M, 5C/30C/50M,30C/100C/200M and 100C/200C/1000M. Homeopathic formulations may includeUrtica dilutions in an amount ranging from about 5% to about 40%, about10% to about 20% relative to the total volume of the final formulation.

Nosodes

Nosodes includes one or more infectious agents in minute doses indilutions. Non limiting examples of Nosodes include various species ofMethicillin-resistant Staphylococcus aureus (MRSA), microplasms,Aspergillus niger, Candida, Mucor racemosus; and infections agents thatact to infect wounds, particularly burn wounds/injuries, that wouldinclude Gram-negative bacteria, and Gram-positive bacteria. Homeopathicformulations in accordance with the present invention can includetinctures and/or dilutions of Nosodes. In some embodiments, a mothertincture of Nosodes can include about 0.1 to about 5 grams of Nosodesdissolved in about 30 to about 60 ml of water and/or alcohol. Variousdilutions can be made from the mother tincture. Dilutions of Nosodes mayinclude X, C and M dilutions. X dilutions may range in potency fromabout mother tincture to about 500 X; about 2 X to about 300 X; about 5X to about 100 X; about 5 X to about 50X. C dilutions may range inpotency from mother tincture to about 500 C; about 2 C to about 300 C;about 5 C to about 100 C; about 5 C to about 50C. M dilutions may rangein potency from about mother tincture to about 1000 M; about 2 M toabout 300 M; about 5 M to about 200 M; about 5 M to about 100 M.Succussion can be performed on any Nosodes dilution, prior to, or afterblending to form a homeopathic formulation. In some embodiments,homeopathic formations can be made from include Nosodes dilutions of12C. In other embodiments, homeopathic formulations can be made fromNosodes dilutions of 30C. In yet other embodiments, homeopathicformulations can be made from Nosodes dilutions of 50M. In anotherembodiment, homeopathic formulations is a blended formulation includingvarious Nosodes dilutions. Examples of such blended formulation, withoutlimitation, includes blended formulation of 12C/30C/50M, 30C/100C/100M,5C/30C/50M, 30C/100C/200M and 100C/200C/1000M. Homeopathic formulationsmay include Nosodes dilutions in an amount ranging from about 3% toabout 40%, about 10% to about 20% relative to the total volume of thefinal formulation.

Formulation

The homeopathic formulation of the present invention comprises at leastone dilution of Arnica, at least one dilution of Calendula, at least onedilution of Echinacea, at least one dilution of Hypericum, at least onedilution of Silver, at least one dilution of Sulfur, at least onedilution of Thiosinaminum, and at least one dilution of Urtica.

The homeopathic formulation of the present invention comprises at leastone dilution of Arnica, at least one dilution of Calendula, at least onedilution of Echinacea, at least one dilution of Hypericum, at least onedilution of Silver, at least one dilution of Sulfur, at least onedilution of Thiosinaminum, and at least one dilution of Urtica. In someembodiments, the dilutions of Arnica is present in an amount rangingfrom about 5% to about 30%, preferably about 10% to about 20%; thedilutions of Calendula is present in an amount ranging from about 5% toabout 30%, preferably about 10% to about 20%; the dilutions of Echinaceais present in an amount ranging from about 5% to about 30%, preferablyabout 10% to about 20%; the dilutions of Hypericum is present in anamount ranging from about 5% to about 30%, preferably about 10% to about20%; the dilutions of Silver is present in an amount ranging from about5% to about 30%, preferably about 5% to about 30%, preferably about 10%to about 20%; the dilutions of Sulfur is present in an amount rangingfrom about 5% to about 30%, preferably about 10% to about 20%; thedilutions of Thiosinaminum is present in an amount ranging from about 5%to about 30%, preferably about 10% to about 20%; and the dilutions ofUrtica is present in an amount ranging from about 5% to about 30%,preferably about 10% to about 20% relative to the total volume of theformulation. The amount of the dilutions may be adjusted depending onthe particular application.

In various embodiments of the formulation, the potency of the at leastone dilution of Arnica ranges from mother tincture to about 1000 M; thepotency of the at least one dilution of Calendula ranges from mothertincture to about 1000 M; the potency of the at least one dilution ofEchinacea ranges from mother tincture to about 1000 M; the potency ofthe at least one dilution of Hypericum ranges from mother tincture toabout 1000 M; the potency of the at least one dilution of Silver rangesfrom mother tincture to about 1000 M; the potency of the at least onedilution of Sulfur ranges from mother tincture to about 1000 M; thepotency of the at least one dilution of Thiosinaminum ranges from mothertincture to about 1000 M; and the potency of the at least one dilutionof Urtica ranges from mother tincture to about 1000 M. The potency ofthe dilutions may be adjusted depending on the particular application.

Solvent

Homeopathic formulations in accordance with the present inventioninclude a solvent. Non limiting examples of the solvent include water,alcohol, oil, any other physiological fluid, and a mixture thereof. Insome embodiments, homeopathic formulations may include a solvent rangingfrom about 0.075% to about 100% relative to the total weight of theformulation.

Inactive Ingredients

Homeopathic formulations in accordance with the present invention mayfurther comprise one or more inactive ingredients, such as excipientsthat are common to the health and/or cosmetic industries, as well asminerals, such as sea minerals. Sea mineral, which can be included inthe homeopathic formulation of the present invention include one or moreof the following elements: Antimony, Barium, Beryllium, Bismuth, Boron,Bromine, Cadmium, Calcium, Carbonate, Cerium, Cesium, Chloride,Chromium, Cobalt, Copper, Dysprosium, Erbium, Europium, Gadolinium,Gallium, Germanium, Gold, Hafnium, Holmium, Indium, Iodine, Iridium,Iron, Lanthanum, Lead, Lithium, Lutetium, Magnesium, Manganese,Molybdenum, Neodymium, Nickel, Niobium, Osmium, Palladium, Phosphorus,Platinum, Potassium, Praseodymium, Rhenium, Rhodium, Rubidium,Ruthenium, Samarium, Scandium, Selenium, Silicon, Silver, Sodium,Strontium, Sulfate/Sulfur, Tantalum, Tellurium, Terbium, Thallium,Thorium, Thulium, Tin, Titanium, Tungsten, Vanadium, Ytterbium, Yttrium,Zinc, Zirconium, plus other naturally occurring trace minerals found inseawater.

Preservative, such as potassium sorbate, can also be included in thehomeopathic formulations. The formulations can include anti-infectionagents/antimicrobial agents that can also act to preserve, for examplesilver. Other medicament, such as opioid, can also be included in thehomeopathic formulations. In a preferred embodiment, opioid is notincluded in the formulation.

The compositions herein taught might also be combined with surfactantsand or items such as Dimethyl sulfoxide (DMSO) that may assist, such as,in the penetration of the skin. Other examples of some excipients usedin accordance with the invention are viscosity modifying agents,buffers, antioxidants, emulsifying agents, absorbents, anti-acne agents,antiperspirants, anticaking agents, antifoaming agents, antimicrobialagents, antioxidants, antidandruff agents, astringents, binders,buffers, biological additives, buffering agents, bulking agents,chelating agents, chemical additives, coupling agents, conditioners,colorants, cosmetic astringents, cosmetic biocides, denaturants, drugastringents, detergents, dispersants, external analgesics, film formers,foaming agents, fragrance components, flavoring agents humectants,keratolytics, opacifying agents, pH adjusters, preservatives,propellants, proteins, retinoids, reducing agents, sequestrants, skinbleaching agents, skin-conditioning agents (humectants, miscellaneous,and occulsive), skin soothing agents, skin healing agents, softeners,solubilizing agents, lubricants, penetrants, plastisizers, solvents andco-solvents, sunscreening additives, sweeteners, salts, essential oils,and vitamins. In some embodiments, homeopathic formulations may includeinactive ingredients ranging from about 0.01 wt % to about 95 wt %relative to the total weight of the formulation.

Mode of Delivery

The homeopathic formulations of the present invention can be prepared invarious forms of preparation desired for administration. The homeopathicformulation can be formulated to be administered orally, parenterally,intravenously, intramuscularly, intrathecally, subcutaneously,sublingually, gingivally, buccally, rectally, vaginally, ocularly,nasally, by inhalation, cutaneously, topically, systematically, andtransdermally. The homeopathic formulations can be formulated asliquids, spray, a drop, e.g., an eye drop, liquid in atomized form via,e.g., a nebulizer, and aerosolized inhaler, capsules, tables, capsules,gel capsules, powders, chewable tablets, dissolvable tablet/sheet,cream, gel, suppository, ring, gel, ointment, lotion, lozenge,(including frozen lozenge), and patch.

In an embodiment, the formulation of the present invention is used inliquid form, and preferably administered as a topical spray, whereinthis spray would be applied directly onto an area/s of concern, whichcould be outside and/or inside the body. The use of this formulationwithin a topical spray for use on the outside the body, could forexample be applied onto such areas such as skin, eyes, ears, joints,feet, hands, back, face, legs, arms, back and any parts of the body. Theformulation can also be sprayed directly onto trunks/pathways, as found,for example, in neck and spinal area, and also nasal cavities, mouth andthroat.

Method of Treatment

The homeopathic formulation of the present invention can be used totreat pain, aches and discomfort in general, and specifically painassociated with burn wounds including all types of 1st, 2nd, 3rd and 4thdegree burns, chemical, scalding, and electrical burns. The homeopathicformulation of the present invention administered via topical spray is amulti-modality aid that provides eight synergistic benefits: (1)stops/relieves pain and discomfort; (2) fights/minimizes infection; (3)stimulates healing and epithelization; (4) reduces inflammation; (5)increases perfusion; (6) prevents/minimizes scar tissue; (7) moisturizeswound/skin and (8) reduces itching/puruitus. In a preferred embodiment,the homeopathic formulation of the present invention is nontoxic,non-addictive, opiate free, taste free, steroid free, non-greasy, safe,non-staining, scent free and hypoallergenic, and therefore can beapplied generally as needed to the area of need liberally. In someembodiments, the formulation is effective in about 5 seconds to 20minutes, preferably about 10 seconds to about 15 minutes.

Other non-limiting examples of the uses of homeopathic formulation ofthe present invention include treatment of general wounds, arthritis,lower back pain, acute and/or chronic pain, sinus, hay fever, allergiesfrostbite, sore/red eyes, rashes, mouth sores, pressure ulcers,neuropathic pain, incisions, and wounds that include burn wounds, musclespasms/sprains, cuts, lacerations, abrasions, surgical incisions, jointpain; insect bites and stings; bruised or injured sore aching areas,repetitive use pain, e.g., carpal tunnel syndrome, abrasions, surgicalcuts, lesions, blisters, rubbed, chafed areas, crotch rot, jungle rot,plant induced inflammation rashes, trigeminal pain, toothpain/discomfort; gum pain/discomfort, inflamed eyes, sore/inflamedthroat, odor abatement, e.g., odor abatement associated with mouth(halitosis/bad breath), wounds, bandage/s, underarm, vagina, menstrualpads/inserts, feet. cancer/cancerous tumors for stasis/remediation/pain,for moisturization of skin, scar tissue minimization, to treatinflammation, to stop itching; to stimulate the body's healing response;for anti-microbial enhancement, to treat irritable bowel syndrome. Theprimary treatment of the condition using the present invention couldprovide the secondary benefit including, but not limited to sleepenhancement, stress/anxiety/depression relief, and cancer/canceroustumors stasis/remediation (such as by increasing immune system functionand enhancing cellular transduction/signaling). The formulation of thepresent invention may also be applied to fruits and vegetables to delayspoilage due to decreased bacterial/enzymatic action.

EXAMPLES

The following are the some examples of the formulation in accordancewith the present invention.

Example 1

A blended dilution can be made as illustrated below in Table 4:

TABLE 4 Volume Active Ingredients Potency (ounces) v/v % Arnica 10C 23.7 Arnica 30C 2 3.7 Arnica 50M 2 3.7 Calendula 10C 2 3.7 Calendula 30C2 3.7 Calendula 50M 2 3.7 Echinacea ANG 10C 2 3.7 Echinacea ANG 30C 23.7 Echinacea ANG 50M 2 3.7 Hypericum 10C 2 3.7 Hypericum 30C 2 3.7Hypericum 50M 2 3.7 Silver 10C 2 3.7 Silver 30C 2 3.7 Silver 50M 2 3.7Sulfur 10C 2 3.7 Sulfur 30C 2 3.7 Sulfur 50M 2 3.7 Thiosinaminum 10C 23.7 Thiosinaminum 30C 2 3.7 Thiosinaminum 50M 2 3.7 Urtica 10C 2 3.7Urtica 30C 2 3.7 Urtica 50M 2 3.7 Nosode: Methicillin-resistant 50M 23.7 Staphylococcus aureus Nosode: Pseudomonas 50M 2 3.7 areuginosa TOTAL54 100

Example 2

A blended dilution can be made as illustrated below in Table 5:

TABLE 5 Volume Active Ingredients Potency (ounces) v/v % Arnica 10C 24.1666 Arnica 30C 2 4.1666 Arnica 50M 2 4.1666 Calendula 10C 2 4.1666Calendula 30C 2 4.1666 Calendula 50M 2 4.1666 Echinacea ANG 10C 2 4.1666Echinacea ANG 30C 2 4.1666 Echinacea ANG 50M 2 4.1666 Hypericum 10C 24.1666 Hypericum 30C 2 4.1666 Hypericum 50M 2 4.1666 Silver 10C 2 4.1666Silver 30C 2 4.1666 Silver 50M 2 4.1666 Sulfur 10C 2 4.1666 Sulfur 30C 24.1666 Sulfur 50M 2 4.1666 Thiosinaminum 10C 2 4.1666 Thiosinaminum 30C2 4.1666 Thiosinaminum 50M 2 4.1666 Urtica 10C 2 4.1666 Urtica 30C 24.1666 Urtica 50M 2 4.1666 TOTAL 48 100

Example 3

A liquid spray can be formulated using the blended formulations ofExample 1 and 2 as shown in Table 6 and 7 below:

TABLE 6 Volume Ingredients (ounces) v/v % Blended Formulation of 54.00095.9863 Example 1 Water 2.000 3.5550 Sea Mineral 0.250 0.4444 Silver0.008 0.0142 TOTAL 56.258 100

TABLE 7 Volume Ingredients (ounces) v/v % Blended Formulation of 48.000095.5081 Example 2 Water 2.0000 3.9795 Sea Mineral 0.2500 0.4974 Silver0.0075 0.0149 TOTAL 50.2575 100

Example 4

The formulations of the invention were used to treat pain associatedwith burn wounds. The formulation in accordance with the presentinvention was topically applied to the burn wounds on hand asillustrated in FIG. 1 each day for 21 days. Total pain relief wasachieved after the first day. As shown in FIG. 2, no infection or scartissue occurred.

Example 5

Two male burn doctors and an another male individual purposely initiatedeight second hot-plate burns on the ring fingers of their right and lefthands. The formulation of the present invention was topically applied byspraying at 0.15 ml/spray onto only one burned finger of each person 5seconds after the fingers were burned, and afterwards every 4 hours. Theother burned finger of each individual was only treated with a standardmeasure of care. Constant nagging pain was felt for days on all of thefingers only treated with a standard measure of care. At no time wasthere any pain experienced by each person on the finger to which theformulation of the present application was topically applied.

Example 6

A male in his 70's with Cellulitis on his left leg, as illustrated inFIG. 3, was in severe pain. His leg was severely inflamed/infected andwas also itching, and was in a negative progression; his leg wasmedically non-responsive, and his prognosis was quickly approachingamputation. After using the formulation in accordance with the presentinvention as an adjunct therapy, within two hours, he experienced nopain and started a positive health progression. He used the formulationfour times a day and continued for nine days and FIG. 4 illustrates thispatient's leg, saved from amputation, treated with the formulation inaccordance with the present invention.

Example 7

A male patient who had received significant incisions/sutures wasexpected to have significant post-operative pain for 3 days. Theformulation in accordance with the present invention was topicallyapplied via spray to the incisions/sutures areas every 30 minutes. Thispatient subsequently experienced no post-operative pain.

Example 8

A female patient in her 60's suffering from trigeminal neuralgiaexperienced excruciating pain shooting across her face, into her eyes,and the electrically exploding in her head for months. Pharmaceuticaldrugs had no positive effect in treating her pain, which was so frequentand intense that it elicited suicidal thoughts. The physician treatingthis female patient recommended anti-depressants and the possibility ofexploratory brain surgery. This female patient topically applied theformulation in accordance with the present invention twelve times to 20times a day to her face. Within 30 days, the pain had become manageableand within 90 days, the pain was minimal.

Example 9

A female patient in her 50's had severe medically unresponsive chroniclower back pain, which developed into such severity that she could notwork. Daily her minute by minute waiting for paroxysmal pain to envelopher body brought deep anxiety, despair and suicidal thoughts. Herphysician suggested anti-depressants and a hip replacement. The patientstarted the topical spray application of the formulation in accordancewith the present invention by spraying 10 to 15 times a day. After 30days, the explosive and overwhelming back pain dramatically diminishedand she returned to work within 45 days.

Example 10

A male patient with severe asthma applied the formulation of the presentinvention to his forehead and upper chest area. Within 2-3, hisbreathing returned to normal and a feeling of balance and relaxationfollowed application of the formulation.

Example 11

A female had frequent pain in her right wrist area, apparently from therepetition from the many years that her work demanded as a hairstylist.After one topical spray application of the formulation in accordancewith the invention, this female had a complete cessation of her wristpain within 5 seconds.

Although the invention herein has been described with reference toparticular embodiments, it is to be understood that these embodimentsare merely illustrative of the principles and applications of thepresent invention. It is therefore to be understood that numerousmodifications may be made to the illustrative embodiments and that otherarrangements may be devised without departing from the spirit and scopeof the present invention as defined by the appended claims.

The invention claimed is:
 1. A method of treating pain comprisingadministering to a patient in need thereof orally, sublingually,gingivally, buccally, rectally, ocularly, nasally, by inhalationtopically, or transdermally a composition comprising therapeuticallyeffective amounts of each of the following dilutions—at least onedilution of Arnica, at least one dilution of Calendula, at least onedilution of Echinacea, at least one dilution of Hypericum, at least onedilution of Silver, at least one dilution of Sulfur, at least onedilution of Thiosinaminum, and at least one dilution of Urtica, whereineach of said at least one dilutions has a potency of at least 10C to thepotency of a mother tincture.
 2. The method of claim 1, wherein thecomposition is formulated as a topical spray and wherein the topicalspray is sprayed directly onto an area of concern on the outside of orinside the patient's body.
 3. The method of claim 2, wherein the topicalspray is applied to the patient's skin, eyes, ears, joints, feet, hands,back, face, neck, spinal area, legs, arms, back, nasal cavities, mouthor throat.
 4. The method of claim 1, wherein the pain is associated withone or more burn wounds.